Info cited on 2017-01-08-WD7 (資訊引用於中華民國106年1月8日) by 湯偉晉
(WeiJin Tang)
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Video 16 Antibody Immunoglobulin Immune Function
John Thomas
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https://youtu.be/EMThHM-YD5k
發佈日期：2014年1月14日
16) Immunoglobulin Function of the five antibodies
Let's take a closer look at the five types of antibody
immunoglobulins.
IgAs are not typically found in the blood, but in secretions
of the gut, saliva, sweat, milk, respiratory track, and urinary track. IgAs are
part of our innate immunity and fight pathogens, such as bacteria, viruses,
fungus and worms. There are two types of IgAs.
IgDs are primarily found on the surface of B-cells and
account for a very tiny portion of the free floating antibodies found in
plasma. And while IgDs are the least well know antibody, they are known to play
a role in the activation of basophils and mast cells to attack invading
microbes.
IgEs respond to allergens, such as pollen as well as
parasitic worms. IgEs bind to mast cells and basophils. Once the IgE receptor
comes into contact with one of these antigens the mast cells and basophils will
release histamine molecules, causing the inflammatory symptoms we know as an
allergic reaction.
There are four types of IgGs. IgGs target pathogenic
organisms, such as bacteria, viruses and parasites. They attach to an antigen
on one end while the opposite end binds with phagocytic white cells
(macrophages, neutrophils, and natural killer cells) to absorb and destroy the
antigen. IgGs are the primary antibody of the
human body, accounting for 70-80% of the entire immunoglobulin pool. It
is the smallest Ig molecule, allowing it to easily migrate into the tissues of
the body. Only 45% are found in the blood. Almost every man made monoclonal
antibody in clinical use is in the IgG family.
IgMs are early responders and function to eliminate
pathogens early on in the attack before there are sufficient levels of IgGs.
IgMs are known as a macroglobulin
because of their large size. They are the largest of the immunoglobulins
and make up 6-10% of the total Ig
pool.
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2017-01-08 Science Talk: Antibody
Neutralizes Two Deadliest Ebola Virus Species;Albert Einstein College of Medicine; 日期：2016年1月13日 Source
(資訊來源): https://www.youtube.com/watch?v=Hh2x1zn5usg
Info cited on 2017-01-08-WD7 (資訊引用於中華民國106年1月8日) by 湯偉晉 (WeiJin Tang)
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Science Talk: Antibody
Neutralizes Two Deadliest Ebola Virus Species;Albert Einstein College of Medicine; 日期：2016年1月13日 #
Science Talk: Antibody
Neutralizes Two Deadliest Ebola Virus Species Albert Einstein College of Medicine
發佈日期：2016年1月13日
http://www.einstein.yu.edu - Jonathan Lai, Ph.D., and colleagues have
engineered the first antibodies that can potentially neutralize the two
deadliest strains of the virus that causes Ebola hemorrhagic fever. The
findings were published online January 13 in the journal Scientific Reports.
Dr. Lai, associate professor of biochemistry at Albert Einstein College of
Medicine, and John Dye, Ph.D., branch chief of viral immunology at USAMRIID,
were co-leaders on the study.
