John Thomas on YouTube - Video 16 Antibody Immunoglobulin Immune Function [2014]
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Antibody Immunoglobulin Immune
Function
John Thomas on YouTube - Video 16 Antibody Immunoglobulin
Immune Function [2014]
Source (資訊來源):
Info cited on 2017-01-08-WD7 (資訊引用於 中華民國106年1月8日) by 湯偉晉
(WeiJin Tang)
#
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Video 16 Antibody Immunoglobulin Immune Function
John Thomas
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https://youtu.be/EMThHM-YD5k
發佈日期：2014年1月14日
16) Immunoglobulin Function of the five antibodies
Let's take a closer look at the five types of antibody
immunoglobulins.
IgAs are not typically found in the blood, but in secretions
of the gut, saliva, sweat, milk, respiratory track, and urinary track. IgAs are
part of our innate immunity and fight pathogens, such as bacteria, viruses,
fungus and worms. There are two types of IgAs.
IgDs are primarily found on the surface of B-cells and
account for a very tiny portion of the free floating antibodies found in
plasma. And while IgDs are the least well know antibody, they are known to play
a role in the activation of basophils and mast cells to attack invading
microbes.
IgEs respond to allergens, such as pollen as well as
parasitic worms. IgEs bind to mast cells and basophils. Once the IgE receptor
comes into contact with one of these antigens the mast cells and basophils will
release histamine molecules, causing the inflammatory symptoms we know as an
allergic reaction.
There are four types of IgGs. IgGs target pathogenic
organisms, such as bacteria, viruses and parasites. They attach to an antigen
on one end while the opposite end binds with phagocytic white cells
(macrophages, neutrophils, and natural killer cells) to absorb and destroy the
antigen. IgGs are the primary antibody of the
human body, accounting for 70-80% of the entire immunoglobulin pool. It
is the smallest Ig molecule, allowing it to easily migrate into the tissues of
the body. Only 45% are found in the blood. Almost every man made monoclonal
antibody in clinical use is in the IgG family.
IgMs are early responders and function to eliminate
pathogens early on in the attack before there are sufficient levels of IgGs.
IgMs are known as a macroglobulin
because of their large size. They are the largest of the immunoglobulins
and make up 6-10% of the total Ig
pool.
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